{ "ok": true, "type": "websdocs_asg_directory_public_profile", "product": "WebsDocs ASG Directory", "clientSlug": "home-scarab-genomics", "directoryOnly": true, "hostedProfile": false, "activeAgent": false, "agentStatus": "directory_only", "businessName": "Home - Scarab Genomics", "legalName": "", "websiteUrl": "https://www.scarabgenomics.com/", "industry": "Scarab Genomics", "timezone": "", "languages": [ "en-US" ], "businessSummary": "Home - Scarab Genomics Link to Facebook Link to X Link to LinkedIn My account Register 1-866-511-5090 Products Vaccine Carrier Proteins CRM197 protein Protein D Clean Genome ® E. coli catalog strains Overview Clean Genome ® Clean Genome ® ΔrecA Clean Genome ® LowMut Clean Genome ® LowMut ΔrecA Blue Clean Genome ® LowMut T7 Additional Clean Genome ® E. coli for dsRNA and Small RNA Production Low Endotoxin Clean Genome® E.", "longDescription": "", "publicContact": {}, "serviceArea": "", "services": [], "offers": [], "products": [ { "name": "CRM197 protein", "description": "Cross-Reactive Material 197 (CRM197) is a non-toxic mutant form of the 58-kd diphtheria toxin that serves as a carrier protein for polysaccharides and haptens in a number of conjugate vaccines, to enhance their immunogenicity. The effectiveness of this approach has been shown with Prevnar®, Pfizer’s Pneumococcal conjugate vaccine, which contains CRM197 conjugated to weakly antigenic sugars to render the vaccine more immunogenic while maintaining disease specificity. CRM197 is the product of a single nucleotide change in the diphtheria toxin gene to create a change from glycine to glutamic acid at position 52 of the protein, disabling the ADP-ribosylation activity of the A chain, thereby attenuating toxicity (Giannini et al., Nucl. Acids Res. 12:4063, 1984; Mekada & Uchida, J. Biol. Chem. 260:12148,1985). At Scarab we produce CRM197 efficiently using a recombinant Clean Genome® E.coli host in our C-FLOW™ continuous fermentation system. This stable and robust process consistently produces CRM197 proteins that meet strict quality specifications, ensuring routine lot-to-lot consistency.   Scarab’s research-grade CRM197 exhibits greater purity than those tested from other vendors by SDS-PAGE. Overcoming non-disease antigen specific immunogenicity There is evidence that CRM197-conjugate vaccines elicit an immune response to CRM197 as well as to the disease antigen. Such immune responses could then impair the effectiveness of subsequent injections of vaccines for the same or other diseases if these vaccines use the CRM197 conjugate. Therefore, future conjugate vaccines ma", "pricingNote": "", "availability": "available", "url": "https://www.scarabgenomics.com/product/crm197-protein/" }, { "name": "Clean Genome®", "description": "Clean Genome® is the most robust bacterial fermentation host for general/routine recombinant protein expression and nucleic acid production", "pricingNote": "", "availability": "available", "url": "https://www.scarabgenomics.com/product/clean-genome/" }, { "name": "Protein D", "description": "Protein D is a 42 kDa surface-exposed lipoprotein from Haemophilus influenzae that is utilized as an effective carrier protein for polysaccharides and haptens in human conjugated vaccines to enhance immunogenicity while maintaining disease antigen specificity. The effectiveness of this approach has been shown with GSK’s Synflorix®, GSK’s Pneumococcal Conjugate, which contains Protein D conjugated to weak antigenic sugars to render them more immunogenic while maintaining disease specificity. Overcoming non-disease antigen specific immunogenicity Use of Protein D-conjugate vaccines may elicit an immune response to the Protein D as well as to the disease antigen. Such immune responses to Protein D could then impair the effectiveness of subsequent injections of vaccines for other diseases if these vaccines use the same conjugate. Therefore, future conjugate vaccines may need to deploy alternative protein conjugates. This is why Scarab Genomics also offers CRM197, which has been successfully used as a conjugate for example in Pfizer’s Prevnar® vaccine. Protein D is for Research Use Only, Not for use in humans or as a diagnostic agent. At Scarab we produce Protein D efficiently using a recombinant Clean Genome® E.coli host in our C-FLOW™ continuous fermentation system. This stable and robust process consistently produces Protein D that meets strict quality specifications, ensuring routine lot-to-lot consistency. Scarab Protein D is > 95 % pure as analysed by SDS-PAGE Note that the electrophoretic mobility of Protein D is anomalous, migrating faster than its 42 kDa mass would lead", "pricingNote": "", "availability": "available", "url": "https://www.scarabgenomics.com/product/protein-d/" } ], "categories": [ { "slug": "healthcare-medical", "name": "Healthcare & Medical", "description": "Clinics, hospitals, doctors, dentists, pharmacies and other healthcare providers." } ], "pricingNotes": { "summary": "", "currency": "", "rule": "", "restrictions": "" }, "routes": {}, "faq": [], "policy": {}, "handoff": {}, "urls": { "base": "https://aig.websdocs.com", "gateway": "https://directory.websdocs.com/business/home-scarab-genomics", "directoryProfile": "https://directory.websdocs.com/business/home-scarab-genomics", "directoryJson": "https://directory.websdocs.com/business/home-scarab-genomics.json", "hostedProfile": "", "hostedJson": "", "hostedLlms": "", "hostedSchema": "", "profile": "https://aig.websdocs.com/ai/home-scarab-genomics/profile", "llms": "https://aig.websdocs.com/ai/home-scarab-genomics/llms.txt", "companyJson": "https://aig.websdocs.com/ai/home-scarab-genomics/data/aig-company-profile.json", "agentCard": "https://aig.websdocs.com/ai/home-scarab-genomics/agent-card.json", "agentCardWellKnown": "https://aig.websdocs.com/ai/home-scarab-genomics/.well-known/agent-card.json", "policy": "https://aig.websdocs.com/ai/home-scarab-genomics/policy", "security": "https://aig.websdocs.com/ai/home-scarab-genomics/security", "pricing": "https://aig.websdocs.com/ai/home-scarab-genomics/pricing", "routes": "https://aig.websdocs.com/ai/home-scarab-genomics/routes", "faq": "https://aig.websdocs.com/ai/home-scarab-genomics/faq", "services": "https://aig.websdocs.com/ai/home-scarab-genomics/services", "offers": "https://aig.websdocs.com/ai/home-scarab-genomics/offers", "commerceReadiness": "https://aig.websdocs.com/ai/home-scarab-genomics/commerce-readiness", "ask": "https://aig.websdocs.com/ai/home-scarab-genomics/ask", "sampleQuestions": "https://aig.websdocs.com/ai/home-scarab-genomics/sample-questions", "robots": "https://aig.websdocs.com/ai/home-scarab-genomics/robots.txt", "schema": "https://aig.websdocs.com/ai/home-scarab-genomics/schema.jsonld" }, "liveCapabilities": { "ask": false, "a2aMessaging": false, "ucp": false, "mcp": false, "checkout": false }, "publicKnowledgeOnly": true, "privateDataAccess": false, "updatedAt": "2026-09-06T13:46:41.810Z" }